1. Orlistat (Xenical, Alli)

Orlistat is one of the most widely recognized weight maintenance medications, available both by prescription (Xenical) and over-the-counter (Alli). It works by blocking the absorption of about 25% of fat from the foods you eat, which helps reduce calorie intake.

Effectiveness: Orlistat can be effective for maintaining weight, especially when combined with a low-fat diet.

Benefits: Since it works locally in the digestive system, it has fewer systemic side effects than other medications.

Considerations: Common side effects include gastrointestinal issues like cramping, gas, and diarrhea, particularly after high-fat meals.

Orlistat is a good option for those who can commit to a low-fat diet and are looking for a non-stimulant weight maintenance medication.

2. Phentermine/Topiramate (Qsymia)

Qsymia combines two medications: phentermine, which suppresses appetite, and topiramate, which promotes feelings of fullness. Originally designed for weight loss, Qsymia can also be used for weight maintenance under medical guidance.

Effectiveness: Qsymia is one of the more potent weight maintenance drugs available, particularly for individuals with obesity.

Benefits: It helps to reduce cravings and the urge to overeat, which can be valuable for maintaining weight loss.

Considerations: Side effects can include dry mouth, insomnia, dizziness, and constipation. It’s not recommended for people with certain medical conditions, such as glaucoma or hyperthyroidism, or for pregnant individuals.

Qsymia may be helpful for those who struggle with hunger and cravings but should only be used with a prescription and careful medical supervision.

3. Liraglutide (Saxenda)

Liraglutide, known by its brand name Saxenda, is a GLP-1 receptor agonist. Originally developed for managing diabetes, it was later approved for weight loss and can also support weight maintenance by regulating appetite.

Effectiveness: Saxenda has shown success in helping individuals maintain weight loss by reducing hunger and calorie intake.

Benefits: It can aid in maintaining weight by promoting satiety and is also linked with improvements in blood sugar levels.

Considerations: Saxenda is administered as a daily injection, which may not be suitable for everyone. Side effects can include nausea, diarrhea, and in some cases, low blood sugar, particularly if you also have diabetes.

Saxenda is a suitable option for those comfortable with injections and who may benefit from additional blood sugar control.

4. Semaglutide (Wegovy)

Semaglutide, branded as Wegovy, is another GLP-1 receptor agonist and works similarly to Saxenda by targeting the appetite-regulating areas of the brain. It’s one of the more recent weight management drugs approved by the FDA, originally for weight loss but also helpful in weight maintenance.

Effectiveness: Wegovy has shown significant promise in maintaining weight by controlling hunger and cravings.

Benefits: It is administered as a weekly injection, which some people find more convenient than daily injections. It also offers potential benefits for blood sugar regulation.

Considerations: Possible side effects include nausea, vomiting, and fatigue. Like Saxenda, it may cause low blood sugar in people with diabetes.

Wegovy is a practical option for those seeking a once-weekly treatment and support with appetite control and blood sugar management.

5. Naltrexone/Bupropion (Contrave)

Contrave combines two drugs, naltrexone, used in addiction treatment, and bupropion, an antidepressant and smoking cessation aid. Together, these medications help control hunger and reduce food cravings.

Effectiveness: Contrave can be effective in helping people maintain weight loss, particularly those who struggle with emotional eating or food cravings.

Benefits: It offers appetite control without the stimulant effect, which may appeal to those sensitive to stimulants.

Considerations: Side effects can include headaches, nausea, and dizziness. It’s not recommended for people with certain health conditions, such as uncontrolled high blood pressure or seizure disorders.

Contrave may be well-suited for those who need help managing cravings and who do not have contraindicated medical conditions.

Tips for Safe and Effective Use of Weight Maintenance Medications

• Consult Your Healthcare Provider: Always talk to your doctor before starting any weight maintenance medication to ensure it’s safe and suitable for you.

• Combine with Healthy Lifestyle Habits: Medications are most effective when paired with a balanced diet, regular exercise, and healthy lifestyle changes.

• Monitor for Side Effects: Be aware of any side effects, and communicate with your healthcare provider to adjust the dosage or switch medications if needed.

• Set Realistic Goals: Medications can aid weight maintenance, but they’re not magic solutions. Focus on sustainable habits for long-term success.